The redox active chelate Fe-PyC3A provides an order of magnitude change in relaxivity by switching between the weakly and strongly contrasting Fe(2+) and Fe(3+) oxidation states, respectively. This activatable relaxivity change is field independent between 1.4T and 11.7T, and far exceeds what is possible with Gd contrast agents. Oxidation state interchange is triggered by biochemical reductants and oxidants such cysteine and hydrogen peroxide. Redox active iron complexes offer a new paradigm for the design of biochemically responsive MRI contrast agents.
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