Abstract #4367

In vivo detection and quantification of plaque rupture using a novel fibrin-binding PET tracer

David Izquierdo-Garcia¹, Himashinie Diyabalanage¹, Ian Ramsay¹, Nick Rotile¹, Adam Mauskapf², Ji-Kyung Choi¹, Thomas Witzel¹, Anna-Liisa Brownell³, Ciprian Catana¹, Peter Caravan¹, and Ilknur Ay¹

¹Athinoula A. Martinos Center for Biomedical Imaging, MGH / Harvard Medical School, Charlestown, MA, United States, ²Department of Medicine, Massachusetts General Hospital, Boston, MA, United States, ³Gordon Center for Medical Imaging, Massachusetts General Hospital, Boston, MA, United States

Detecting high-risk atherosclerotic plaques prone to rupture is still one of the main challenges in cardiovascular imaging that could help save many lives.

This study presents a novel fibrin-binding positron emission tomography (PET) radiotracer, ⁶⁸Ga-CM246, which allows accurate detection and quantification of plaque rupture in an animal model of atherosclerosis using simultaneous PET/MRI. Our in vivo PET results show that ⁶⁸Ga-CM246 is highly sensitive and very specific to fibrin clots in ruptured plaques.

Our results confirm the potential of the ⁶⁸Ga-CM246 to translate into the clinic to identify in humans those plaques at risk of rupture showing intraplaque hemorrhage.

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