Abstract #4329

Joint estimation of activity and attenuation using 68Ga-PSMA TOF PET/MR in patients with hip endoprosthesis

Edwin E.G.W. ter Voert^1,2, Sangtae Ahn³, Florian Wiesinger⁴, Kristen A. Wangerin⁵, Ken Kudura¹, Urs J. Muehlematter¹, and Irene A. Burger¹

¹Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland, ²University of Zurich, Zurich, Switzerland, ³GE Global Research, Niskayuna, NY, United States, ⁴GE Healthcare, Munich, Germany, ⁵GE Healthcare, Waukesha, WI, United States

Accurate PET attenuation correction remains challenging in PET/MR. Skeletal bone is usually not included and metal implants can cause serious artifacts. In this study we investigate the application of the ‘joint estimation of activity and attenuation’ PET reconstruction algorithm, using MR based priors, in prostate cancer patients with metal hip implants who were scheduled for 68Ga-PSMA TOF PET/MR. The results indicate that, even with the low background-signal of this tracer, the JE algorithm can recover most of the metal hip implant(s), thereby potentially improving the PET attenuation map as well as the activity images.

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