Abstract #4312

Cardiac metabolic imaging using hyperpolarized [1-13C]lactate as a substrate

Angus Z Lau^1,2, Albert P Chen³, and Charles H Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ³GE Healthcare, Toronto, ON, Canada

The use of hyperpolarized [1-¹³C]lactic acid as a substrate for studying cardiac metabolism is attractive due to its high safety profile. ¹³C metabolite images were acquired following injection of hyperpolarized [1-¹³C]lactate in the porcine heart. The appearance of ¹³C-bicarbonate and absence of ¹³C-pyruvate in these images demonstrates rapid decarboxylation of pyruvate within the cardiac tissue.

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