Abstract #4311

Feasibility and Reproducibility of Imaging Brain Metabolism Using Hyperpolarized 13C Pyruvate in Humans

Jae Mo Park^1,2,3, Jeff Liticker¹, Crystal E Harrison¹, Galen D Reed⁴, Thomas Hever⁵, Junjie Ma¹, Richard Martin⁵, Dirk Mayer⁶, Ralph S Hashoian⁷, Christopher J Madden⁸, Marco C Pinho², and Craig R Malloy^1,9

¹Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, ²Radiology, University of Texas Southwestern Medical Center, Dallas, TX, United States, ³Electrical and Computer Engineering, University of Texas Dallas, Richardson, TX, United States, ⁴GE Healthcare, Dallas, TX, United States, ⁵University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁶University of Maryland, Baltimore, Baltimore, MD, United States, ⁷Clinical MR Solutions, Brookfield, WI, United States, ⁸Neurosurgery, University of Texas Southwestern Medical Center, Dallas, TX, United States, ⁹Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States

Human brain metabolism was investigated using hyperpolarized [1-¹³C]pyruvate and [2-¹³C]pyruvate in vivo. Each subject received hyperpolarized pyruvate intravenously with a 45-min interval between the injections. [1-¹³C]lactate and [¹³C]HCO₃^– were consistently detected from hyperpolarized [1-¹³C]pyruvate. [5-¹³C]Glutamate was measured from hyperpolarized [2-¹³C]pyruvate. The levels of production and relative intensities of the ¹³C-labeled metabolites were reproducible.

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