Abstract #4221

Non-invasive intracranial detection of the small molecule inhibitor BAY 1436032 in an orthotopic glioma model using 19F MR spectroscopy

Katharina J Wenger¹, Michael Burger², Christian Richter³, Joachim Steinbach², Harald Schwalbe³, Stefan Kaulfuss⁴, Elke Hattingen¹, Bähr Oliver², and Ulrich Pilatus¹

¹Neuroradiology, University Hospital Frankfurt, Frankfurt, Germany, ²Neurooncology, University Hospital Frankfurt, Frankfurt, Germany, ³Institute for Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt, Germany, ⁴Research&Development Pharmaceuticals, Bayer AG Berlin, Berlin, Germany

BAY 1436032 is a small-molecule inhibitor of the R132X-mutant form of IDH1 with a trifluoromethoxy-group that is currently clinically investigated in IDH1-mutant solid tumors. Non-invasive monitoring of intracranial drug delivery of BAY 1436032 in an animal model using ¹⁹F MRS is technically challenging but feasible.

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