Dynamic 17O-MRI enables a direct measurement of the cerebral metabolic rate of oxygen (CMRO2). Decreased CMRO2 in tumor tissue indicates a change in the metabolic pathway and therefore metabolic imaging can be used as a diagnostic parameter. Data of three high grade tumor patients where investigated with regard to cerebral blood volume (CBV) hyper-intense and apparent diffusion coefficient (ADC) hypo-intense areas to exclude bias of perfusion and ADC. No significant change in CBV+ and ADC- volumes demonstrates the independence of tissue perfusion and cellular density of utilized method and underline the capability of fully quantitative metabolic imaging.
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