Abstract #4214

Longitudinal heterogeneity of post-exercise perfusion, T2*-weighted MRI and high-energy phosphate metabolism in human calf muscle quantified by interleaved multislice 1H MRI and multivoxel 31P MRS at 7T

Fabian Niess^1,2, Albrecht Ingo Schmid^1,2, Wolfgang Bogner^2,3, Michael Wolzt⁴, Pierre Carlier⁵, Ewald Moser^1,2, and Martin Meyerspeer^1,2

¹Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ²MR Center of Excellence, Medical University of Vienna, Vienna, Austria, ³Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ⁴Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria, ⁵NMR Laboratory, Institute of Myology, Paris, France

Multivoxel ³¹P semi-LASER was used to acquire time-resolved spectra from two positions along the gastrocnemius medialis muscle during rest, exercise and recovery. Simultaneously, quantitative perfusion- and T₂*-weighted images of the calf were acquired with multislice ¹H ASL MRI, in an interleaved fashion. Significantly different results were found with ³¹P MRS along gastrocnemius medialis: proximally, end-exercise PCr depletion was higher, PCr recovery times longer, end-exercise pH was lower and maximum oxidative capacity was also lower. Significantly higher post-exercise perfusion and slightly stronger T₂*-weighted signal increase were found in proximal slices, which is consistent with the aforementioned distribution of metabolic activity.

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