Abstract #4148

129Xe Gas-Exchange MRI in Pediatrics with Lung Disease

Matthew M. Willmering¹, Ziyi Wang², Hui Wang^1,3,4, Laura L. Walkup¹, Bastiaan Driehuys^2,5, Zackary I. Cleveland^1,4,6, and Jason C. Woods^1,4,6

¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ²Duke University, Durham, NC, United States, ³Philips, Cincinnati, OH, United States, ⁴University of Cincinnati, Cincinnati, OH, United States, ⁵Duke University Medical Center, Durham, NC, United States, ⁶University of Cincinnati Medical Center, Cincinnati, OH, United States

The solubility properties of hyperpolarized ¹²⁹Xe have made it attractive in many translational pulmonary imaging studies; the large chemical-shift range can be exploited to obtain semi-quantitative ventilation, barrier-uptake, and RBC-transfer images. To date, the technique has demonstrated significant changes in gas exchange in adult lung disease, but has yet to be explored in children, where pulmonary function testing can be more challenging (or impossible). This pediatric gap caused us to pursue ¹²⁹Xe gas-exchange MRI at the now-common field of 3T; here, we present the first demonstration of dissolved-phase xenon imaging in pediatrics (with cystic fibrosis and post-bone marrow transplant).

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