Abstract #4147

Initial Comparison of 19F and Hyperpolarized 129Xenon Gas Lung Imaging in Cystic Fibrosis

Andrew M McCallister^1,2, Sang H Chung^2,3, Michael Antonacci^1,2, Yueh Lee^2,4, Jennifer Goralski⁵, Scott Donaldson⁶, and Rosa T Branca^1,2

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³UNC/NCSU Joint Department of Biomedical Engineering, Chapel Hill, NC, United States, ⁴Radiology and Physics, UNC School of Medicine, Chapel Hill, NC, United States, ⁵Departments of Medicine and Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ⁶Pulmonary Diseases and Critical Care Medicine, UNC School of Medicine, Chapel Hill, NC, United States

Gas enhanced MRI has the potential to provide regional information about lung function that pulmonary function tests alone cannot provide. Hyperpolarized xenon gas is a well-established tool for the assessment of regional lung function in humans, and ¹⁹F gas MRI has been proposed as a lower cost alternative that can provide, in addition to ventilation defects, wash in and wash out rates. Here we report the initial findings of a study aiming at comparing these two techniques for assessment of lung ventilation function in subjects with cystic fibrosis.

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