Abstract #4130

Absolute MR thermometry by hyperpolarized 129Xe in UCP1-/- animals reveals UCP1-independent thermogenesis

Michael A Antonacci^1,2, Christian McHugh^1,2, Michele Kelley^1,2, Andrew McCallister^1,2, and Tamara Branca^1,2

¹Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Direct and non-invasive temperature measurements of BAT in UCP1-/- mice could help to settle the debate on whether BAT in UCP1-/- mice is thermogenically competent and whether there exist other UCP1-independent mechanisms for non-shivering thermogenesis. Here we use hyperpolarized xenon MR thermometry for direct absolute temperature measurements of brown adipose tissue in UCP1-/- mice. Hyperpolarized xenon MR thermometry indicates a small but detectable temperature increase in the BAT of UCP1-/- mice after adrenergic stimulation of this tissue.

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