Abstract #4071

Fetal Brain Tissue Characterization at 1.5 T using STAGE

Feifei Qu¹, Taotao Sun², Yongsheng Chen^1,3, Brijesh Kumar Yadav^1,4, Ling Jiang², Zhaoxia Qian², and Ewart Mark Haacke^1,3,4

¹Department of Radiology, Wayne State University School of Medicine, DETROIT, MI, United States, ²Department of Radiology, International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China, ³The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, ⁴Department of Biomedical Engineering, College of Engineering, Wayne State University, DETROIT, MI, United States

MRI-based tissue properties such as T₁ and proton spin density are known to be important biomarkers of fetal brain maturation. However, fetal motion poses a big challenge in MRI due to long scan durations. Henceforth, there is lack of knowledge about the MRI properties of the human fetal brain tissue. To address these issues, in this study we use a rapid multiparametric method referred to as Strategically Acquired Gradient Echo (STAGE) imaging to obtain T₁ and proton density maps of the fetal brain and generate T1-weighted images with enhanced tissue contrast in two minutes.

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