Abstract #3960

In-Vivo Quantification of Aortic Stiffness using a Multi-Slice Spin-Echo Echo-Planar Imaging Sequence: A Comparison to a Gradient-Recalled Echo Sequence

Huiming Dong^1,2, Ning Jin^3,4, Prateek Kalra¹, Richard White^1,4, and Arunark Kolipaka^1,2,4

¹Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, ²Department of Biomedical Engineering, The Ohio State University, Columbus, OH, United States, ³Siemens Healthcare USA, Columbus, OH, United States, ⁴Internal Medicine-Cardiovascular Division, The Ohio State University Wexner Medical Center, Columbus, OH, United States

Aortic stiffness is an important biomarker of cardiovascular diseases. Magnetic Resonance Elastography (MRE) is a non-invasive tool for measuring in-vivo aortic stiffness. Gradient-Recalled Echo (GRE) MRE sequences are widely employed for aortic MRE. However, GRE MRE sequences are sensitive to T2* decay, leading to signal loss and lower Signal-to-Noise Ratio (SNR). In this work, a cardiac-gated Spin-Echo Echo-Planar Imaging (SE-EPI) MRE sequence was developed and validated against GRE MRE. Similar aortic stiffness was observed between the two techniques. Moreover, shorter scan time, higher first-harmonic amplitude, and Octahedral Shear Strain-Based SNR (OSS-SNR) were achieved using SE-EPI MRE (p<0.05).

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