Abstract #3816

Longitudinal Registration for Voxel-wise Correlation of MRgFUS Treatment Assessment Metrics

Sara L Johnson¹, Blake Zimmerman¹, Jill Shea², Elaine Hillas², Henrik Odéen³, Sarang Joshi¹, and Allison Payne³

¹Biomedical Engineering, University of Utah, Salt Lake City, UT, United States, ²Department of Surgery, University of Utah, Salt Lake City, UT, United States, ³Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States

The acute assessment of MRgFUS therapies with metrics such as thermal dose and contrast-enhanced (CE) imaging have been shown to under- or over-estimate the final ablation lesion as assessed by delayed imaging or histological outcomes. The aim of this study is to longitudinally register MRgFUS treatment images to a final lesion outcome as determined by CE-T1w imaging three days post-treatment for voxel-wise analysis of these errors. MR thermometry (MRTI), cumulative thermal dose (CTD), and acute CE-T1w images are co-registered to Day 3 CE-T1w with millimeter accuracy and assessed for their predictive value.

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