Focused ultrasound has been a fast developing technology for non-invasive neuromodulation. Monkey is a good animal model for studying the mechanism of focused ultrasound on neural network. However, the ultrasound beam would be greatly attenuated and distorted by the monkey skull, making the precise focal localization a crucial step. MR-ARFI with little thermal effect was an attracting tool for focus localization. In this study, we investigated the transcranial MR-ARFI in monkey at 3T system. With high performance of the customer designed monkey head coil and the strong gradient system, reliable and repeatable results were obtained.
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