Abstract #3758

The role of perivascular spaces in white matter blood oxygenation level dependent MRI

Jonathan Doucette^1,2, Laura Kim^1,2, Enedino Hernández-Torres^1,3, Friedrich Anastasopoulos⁴, Christian Kames^1,2, and Alexander Rauscher^1,3,5

¹UBC MRI Research Centre, Vancouver, BC, Canada, ²Physics and Astronomy, University of British Columbia, Vancouver, BC, Canada, ³Pediatrics, University of British Columbia, Vancouver, BC, Canada, ⁴Physics and Astronomy, Heidelberg University, Heidelberg, Germany, ⁵Division of Neurology, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada

Using vascular parameters obtained from dynamic susceptibility contrast MRI, the gradient echo and spin echo blood oxygenation level dependent (BOLD) signals were simulated at 3 and 7T in order to investigate the effects of tissue orientation and perivascular spaces. We show that both the magnitude and the tissue orientation dependence of the BOLD effect is amplified by perivascular spaces.

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