Two types of hemodynamic response function (HRF) are used in the data analysis of ASL based perfusion fMRI (ASL-fMRI): single gamma function (1-gamma) and the sum of two gamma functions (2-gamma). This study aims to optimize the selection of HRF by comparing the performances of standard 1-gamma and 2-gamma HRFs and also a modified 2-gamma HRF, which has earlier response peak time than the standard one. Our visual ASL-fMRI experiment indicate that the modified 2-gamma provides the best detection sensitivity and we recommend to use it in ASL-fMRI.
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