Abstract #3706

Whole-brain OEF quantification: a comparison study between QSM and dual-gas calibrated BOLD

Yuhan Ma¹, Hongfu Sun², Junghun Cho^3,4, Erin L. Mazerolle², Yi Wang^3,4, and G. Bruce Pike^1,2

¹McConnell Brain Imaging Centre and Department of Biomedical Engineering, McGill University, Montreal, QC, Canada, ²Hotchkiss Brain Institute and Department of Radiology, University of Calgary, Calgary, AB, Canada, ³Department of Biomedical Engineering, Cornell University, Ithaca, NY, United States, ⁴Department of Radiology, Weill Cornell Medical College, New York, NY, United States

The microvascular QSM approach for quantifying baseline brain oxygen metabolism has great potential due to its simple set-up and high spatial resolution. In this study, we aim to investigate the feasibility of the high SNR microvascular QSM-OEF technique with a hypercapnia gas challenge and compare OEF and CMRO₂ measured by QSM-OEF with those measured using the dual-gas calibrated BOLD technique (DGC-BOLD-OEF), a reference standard. Baseline OEF and CMRO₂ measured by hypercapnia QSM-OEF were found within the expected normal range for healthy subjects. Statistically significant but relatively small differences (5% difference) of OEF and CMRO₂ were found between QSM-OEF and DGC-BOLD-OEF techniques.

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