Abstract #3705

Normal variations in brain oxygen extraction fraction (OEF) are partly attributed to differences in end-tidal CO2

Dengrong Jiang¹, Zixuan Lin¹, Peiying Liu², Sandeepa Sur², Cuimei Xu², George Pottanat², Kaisha Hazel², Sevil Yasar³, Paul Rosenberg⁴, Marilyn Albert⁵, and Hanzhang Lu²

¹Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁴Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ⁵Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Quantitative assessment of brain oxygen extraction fraction (OEF) is of substantial clinical significance in many brain diseases. However, a remaining issue associated with OEF is its considerable inter-subject variations within healthy population. Therefore, it is important to investigate the physiological underpinnings of OEF variations among normal subjects. The present work used two studies, a discovery study and a verification study, to examine the extent to which end-tidal CO₂ (EtCO₂) can explain inter-subject variations in OEF. It was found that, across subjects, OEF is inversely correlated with EtCO₂, and EtCO₂ alone can account for about 50% of variances in OEF.

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