The
purpose of this study was to more quantitatively characterize the
cytoarchitecture of cortical tissue from microscopy in order to simulate
diffusion signal in the cortex and to better understand its changes with
density, size and permeability of cell bodies, axons and dendrites. Two
random walk simulation methods are presented which show effects of cortical
laminar microstructure on ADC and K. This could open possibilities of detecting
cortical cytoarchitecture, i.e. cell body sizes and densities, and their
pathologies with diffusion MRI.
