Abstract #3545

Surface-to-Volume ratio mapping using Oscillating Gradient Diffusion (OGSE) Spectroscopy for cancer characterization in the ex-vivo prostate

Jeevan Shah¹, Roger Bourne², Geoffrey Watson³, and Andre Bongers¹

¹The University of New South Wales, Sydney, Australia, ²The University of Sydney, Sydney, Australia, ³Royal Prince Alfred Hospital, Sydney, Australia

This study investigates mapping of Surface-to-Volume (S/V) ratios from short diffusion time derived ADC maps to detect and characterize prostate cancer. ADC was mapped using a cos-OGSE DWI (f_osc=50-200Hz) in one unfixed prostate (Gleason 4+4). Using a previously established model, S/V and free cytosol diffusivity (D₀) maps were estimated by fitting the temporal behaviour of ADC. S/V and D₀ were able to clearly and significantly separate the cancer and normal peripheral zone as indicated by a t-test and ROC curves. The geometrical nature of S/V may provide additional information to better characterize prostate cancer independent from diffusion related parameters.

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