1Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Translational Imaging Research Center, Taipei Medical University Hospital, Taipei, Taiwan, 4Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan, 5Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, 6Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan, 7Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan