Structural connectivity between cerebellum and cerebral cortex in idiopathic generalized epilepsy: a diffusion tensor imaging study

Probabilistic tracking method was applied to study the cerebellar efferent and afferent fibers in the patients with idiopathic generalized epilepsy (IGE), trying to address the structural connectivity (SC) alteration in the cerebello-cerebral circuit compared with healthy controls. Present findings suggested cerebellar effects on ganglia-thalamo-cortical circuit, which might be responsible for motion and cognition impairments in IGE. Furthermore, unbalanced SC alterations in the efferent and afferent fibers between frontal cortex and cerebellum might help to understand specific physiopathologic mechanism in IGE.