Sensorineural hearing loss is increasingly recognized as the result of alterations in the auditory-related network. The present study aimed to further explore the whole brain abnormalities of neural network connections in idiopathic sudden sensorineural hearing loss (ISSNHL) through diffusion spectrum imaging. It was found left-sided ISSNHL exhibited decreased connectivity between the contralateral inferior temporal gyrus and rolandic operculum, and the contralateral heschl gyrus and superior marginal gyrus; while increased connectivity was detected between the ipsilateral temporal pole and cuneus, which suggests that DSI could help investigate the structural correlates of these imaging abnormalities in this disease.
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