Abstract #3215

In Vivo MRI characterization of the effect of neuroprotection after nerve agent poisoning in rats

Alexandru V Korotcov^1,2, Asamoah Bosomtwi^1,2, Ranjini Vengilote³, Narayanan Puthillathu³, John Moffett³, Arun Peethambaran³, Andrew Knutsen^1,2, Shalini Jaiswal^1,2, Nathanael Allison^1,4, Aryan M Namboodiri³, and Bernard J Dardzinski^1,4

¹Radiology & Radiological Sciences, Uniformed Service University, Bethesda, MD, United States, ²Center for Neuroscience and Regenerative Medicine, Henry M. Jackson Foundation, Bethesda, MD, United States, ³Anatomy, Physiology and Genetics, Uniformed Service University, Bethesda, MD, United States, ⁴Center for Neuroscience and Regenerative Medicine, Uniformed Service University, Bethesda, MD, United States

Organophosphate poisoning is a major public health problem in developing countries. Organophosphates cause prolonged seizures and leads to neurodegeneration and functional defects. Current therapies are largely ineffective. Several advanced neuroimaging techniques demonstrate promise to detect subtle changes in brain activity and morphology related to organophosphate nerve agent poisoning, which would allow for the in vivo assessment of new therapeutics. In this study we use in vivo MRI and immunohistochemistry to demonstrate that fluorinated volatile anesthetics are an effective post-exposure neuroprotectant and can be used for organophosphates poisoning treatment.

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