Abstract #3214

Spectroscopy and sodium analysis of dissociated cellular therapy in acute ischemia at 21.1 T

Shannon Helsper^1,2, F. Andrew Bagdasarian^1,2, Xuegang Yuan², Nastaren Abad^1,2, Jens T. Rosenberg¹, Teng Ma², and Samuel Colles Grant^1,2

¹National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ²Chemical & Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

This study evaluates biochemical markers in a rat model of acute ischemia at 21.1 T following administration of human mesenchymal stem cells dissociated (d-hMSC) from 3D aggregates utilizing sodium (²³Na) chemical shift imaging (CSI) and relaxation-enhanced MRS. High field ¹H MRS provides sensitive longitudinal metabolic mapping of biological markers including lactate, NAA, creatine and choline in response to cellular treatment. Evaluation of ²³Na CSI provides insight into cerebral ionic homeostasis and tissue recovery following acute neurodegeneration by tracking ischemic lesion volumetrics.

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