Abstract #3205

Performance of sodium, ultrafast diffusion, and MPIO stem cell tracking MRI classification of sub-acute ischemic stroke recovery at 21.1T

Avigdor Leftin^1,2,3, Jens Rosenberg⁴, Xuegang Yuan⁵, Teng Ma⁵, Samuel Colles Grant^4,5, and Lucio Frydman^2,4

¹Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY, United States, ²Chemical and Biological Physics, Weizmann Institute of Science, Rehovot, Israel, ³Radiology, Stony Brook Medicine, Stony Brook, NY, United States, ⁴National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, ⁵Chemical and Biomedical Engineering, FAMU-FSU College of Engineering, Tallahassee, FL, United States

MRI leverages multiple modes of contrast to characterize stroke. Acute phase stroke detection has focused on multiparametric MRI contrasts such as T₂-weighting (T_2w), apparent diffusion coefficient (ADC), and sodium level. Evaluation of these contrasts with theranostic cell tracking during the subacute recovery phase at ultrahigh field has not been investigated to a similar extent. Here multiparametric MRI evaluation of ADC, ²³Na, and MPIO stem cell tracking in a rodent MCAO model at 21.1T was used to determine parametric correlations and receiver operator performance. Differential parametric time-dependence and sensitivities are observed that inform future high-and low field studies of stroke recovery.

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