Abstract #3176

Cerebral myo-inositol and glutamate+glutamine levels assessed by magnetic resonance spectroscopy in healthy aging

Antoine Hone-Blanchet¹, Lisa Krishnamurthy², Salman Shahid¹, Qixiang Lin¹, Candace Fleischer³, James Lah¹, Allan Levey¹, Deqiang Qiu^3,4, and Bruce Crosson¹

¹Neurology, Emory University, Atlanta, GA, United States, ²Physics and astronomy, Georgia State University, Atlanta, GA, United States, ³Radiology and Imaging Sciences, Emory University, Atlanta, GA, United States, ⁴Joint Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, United States

This study aims at measuring the effect of aging and expression of protein amyloid-beta (Aβ) on markers of neuroinflammation and glutamate metabolism using magnetic resonance spectroscopy. Measures of medial frontal cortical myo-inositol (mI) and glutamate+glutamine (Glx) were obtained in 21 young adults, 21 healthy older adults and 10 healthy older adults expressing Aβ. Results show an increase in mI in all older adults compared to young adults, and a decrease in Glx in all older adults compared to young adults. These results suggest that MRS is a viable tool in the investigation of biomarkers of inflammation in aging.

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