Abstract #3175

Susceptibility and Volume Changes of the Mammillary Bodies as a Function of Age for Healthy Individuals and Early Stage Dementia

Zhijia Jin¹, Sean K. Sethi^2,3, Binyin Li⁴, Naying He¹, Weibo Chen⁵, E. Mark Haacke⁶, and Fuhua Yan¹

¹Department of Radiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ²Magnetic Resonance Innovations, Inc., Bingham Farms, MI, United States, ³The MRI Institute for Biomedical Research, Bingham Farms, MI, United States, ⁴Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, ⁵Philips Healthcare, Shanghai, China, ⁶Department of Radiology, Wayne State University, Detroit, MI, United States

The mammillary bodies play an important role in episodic memory and spatial memory. However, few studies have focused on their properties in humans due to the limitations of the imaging techniques, their location and small size. In this study, we evaluate brain iron content and volume of the mammillary bodies in subjects with mild cognitive impairment (MCI), Alzheimer’s Disease and healthy individuals using quantitative susceptibility mapping and 3D T1-weighted imaging. There was a slight reduction in volume and increase in susceptibility with age and there were no differences of either susceptibility or volume among the three groups.

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