Abstract #3134

Hippocampal subfield segmentation and partial volume effects - reliability assessment

Arturo Cardenas-Blanco^1,2, Yi Chen², Jose-Pedro Valdes-Herrera³, Renat Yakupov¹, Hendrik Mattern⁴, Alessandro Sciarra⁴, David Berron⁵, Anne Maass¹, Oliver Speck^1,4,6,7, and Emrah Duezel^1,2

¹German center for neurodegenerative diseases (DZNE), Magdeburg, Germany, ²Institute of cognitive neurology and dementia research, Magdeburg, Germany, ³Aging & Cognition Research Group, German center for neurodegenerative diseases (DZNE), Magdeburg, Germany, ⁴Department of Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany, ⁵Department of clinical sciences, Clinical memory research unit, Malmoe, Sweden, ⁶Center for Behavioral Brain Sciences, Magdeburg, Germany, ⁷Leibniz Institute for Neurobiology, Magdeburg, Germany

The hippocampus is involved in a variety of cognitive and functional tasks. Research groups rely on volumetric segmentations to assess: the integrity of the HC and its subfields as well as their involvement in cognitive tasks. Unfortunately, due to its size and location, most studies use non-isotropic T₂-weighted images to segment the HC. The aim of this project is to determine whether partial volume effects due to T₂-weighted slice angulation and non-isotropic resolution have an impact in the segmentation process. The results indicate that both, angulation and non-isotropic acquisition have a significant impact in specific subfields.

This abstract and the presentation materials are available to members only; a login is required.

Join Here