Abstract #2906

Differentiation between glioma recurrence and treatment effects using DWI, ASL, proton MRS and amide proton transfer (APT) imaging at 3 Tesla

Jie Liu¹, Yinsheng Chen², Cong Li², Xiaofei Lv³, Zhongping Chen², Hairong Zheng¹, and Yin Wu¹

¹Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China, ²Department of Neurosurgery, Cancer Center, Sun Yat-Sen University, Guangzhou, China, ³Department of Medical Imaging, Cancer Center, Sun Yat-Sen University, Guangzhou, China

Conventional MR structural imaging is insufficient for assessment of posttreatment gliomas and advanced imaging is needed to improve diagnostic certainty. The present study compared DWI, ASL, proton MRS and APT for distinction between glioma recurrence and treatment effects. Total 25 patients were enrolled. Results show similar diagnostic performance of APT and ASL, both of which could distinguish recurrent tumor from treatment lesion (P<0.05) with AUC greater than 0.8, superior to that of ADC and proton MRS. Herein, APT and ASL would facilitate posttreatment glioma diagnosis.

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