Abstract #2850

MRI features of the third ventricle subventricular zone suggest differing optic pathway glioma pathology for neurofibromatosis type-1 and sporadic paediatric cases

Natalie R Boonzaier¹, Patrick W Hales¹, Felice D'Arco², Bronwen C Walters^3,4, Ramneek Kaur¹, Kshitij Mankad², Jessica Cooper², Alki Liasis³, Sian E Handley³, Patricia O'Hare⁵, Darren Hargrave⁵, and Christopher Clark¹

¹Developmental Imaging and Biophysics Section, UCL Great Ormond Street Institute of Child Health, London, United Kingdom, ²Radiology Department, Great Ormond Street Children's Hospital, London, United Kingdom, ³Ophthalmology Department, Great Ormond Street Children's Hospital, London, United Kingdom, ⁴Great Ormond Street Hospital for Children NHS Foundation Trust, Great Ormond Street Children's Hospital, London, United Kingdom, ⁵Haematology and Oncology Department, Great Ormond Street Children's Hospital, London, United Kingdom

Paediatric optic pathway glioma (OPG) is a low-grade glioma whose cells likely originate from the subventricular zone of the third ventricle (TVZ). Neurofibromatosis type-1 (NF1) OPG is less clinically aggressive than sporadic OPG, being less likely to cause visual function deficit. Using measures of migrating tumour activity, this study analysed the imaging profiles at the TVZ. Apparent diffusion coefficient (ADC) and cerebral blood flow (CBF) profiles associated with migrative tumour cell activity were detected at the TVZ and correlated with poor visual function in sporadic, but not NF1-associated, cases. These results suggest that MRI can identify imaging characteristics that differentiate sporadic and NF1-associated OPG.

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