Abstract #2548

Effects of Transcranial Direct Current Stimulation on Metabolite Concentrations in Children

Chidera Nwaroh^1,2,3,4, Lauran Cole^2,3,5,6, Adrianna Giuffre^2,3,5,6, Helen Carlson^2,6,7, Frank P MacMaster^{2,3,4,7,8,9,10}, Adam Kirton^2,3,6,7, and Ashley D Harris^1,2,3,4

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Alberta Children's Hospital Research Institute (ACHRI), Calgary, AB, Canada, ³Hotchkiss Brain Institute, Calgary, AB, Canada, ⁴Child and Adolescent Imaging Research (CAIR) Program, Calgary, AB, Canada, ⁵Department of Neuroscience, University of Calgary, Calgary, AB, Canada, ⁶Calgary Pediatric Stroke Program, Alberta Children's Hospital, Calgary, AB, Canada, ⁷Department of Pediatrics, University of Calgary, Calgary, AB, Canada, ⁸Department of Psychiatry, University of Calgary, Calgary, AB, Canada, ⁹The Mathison Centre for Mental Health Research and Education, University of Calgary, Calgary, AB, Canada, ¹⁰Strategic Clinical Network for Addictions and Mental Health, Calgary, AB, Canada

Transcranial direct current stimulation (tDCS) is a form of non-invasive brain stimulation that safely modulates brain activity. Several studies have shown that tDCS of the motor cortex facilitates motor learning and plasticity but there is little information on the underlying mechanisms. This analysis of metabolite changes in response to 1mA tDCS using typical PRESS and MEGA-PRESS is important in developing a complete understanding of the effects of stimulation. In this pediatric study, we did not detect the same GABA and glutamate changes in response to tDCS that have been seen in the adult literature.

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