Abstract #2479

Non-Water suppressed High-Resolution 1H-MRSI of the Brain Using Short-TE SPICE with semi-LASER Concentric Ring Trajectory Acquisition

Uzay Emir^1,2, Pingyu Xia¹, Ulrike Dydak^1,3, Xiaopeng Zhou¹, Albert Thomas⁴, Mark Chiew⁵, Rong Guo^6,7, Yudu Li^6,7, Yibo Zhao^6,7, and Zhi-Pei Liang^6,7

¹School of Health Sciences, Purdue University, West Lafayette, IN, United States, ²Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States, ³Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, United States, ⁴Department of Radiology, University of California Los Angeles, Los Angeles, CA, United States, ⁵6Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, United Kingdom, ⁶Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Illinois 2Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Illinois Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champaign, IL, United States, ⁷Department of Electrical and Computer Engineering, University of Illinois, Urbana-Champaign, IL, United States

Magnetic resonance spectroscopic imaging (MRSI) is an appealing technique in both research and clinical settings. However, the utility of MRSI has been hampered by long acquisition times and artifacts caused by lipid contamination and poor water suppression. Recent advances in MRSI acquisition and preprocessing, like concentric rings (CRT) trajectories and SPICE (SPectroscopic Imaging by exploiting spatiospectral CorrElation) (REF3), have overcome some of these issues. This work reports our success in integrating SPICE with CRT acquisitions to address the challenges of sensitivity, spectral quality, speed, and spatial resolution.

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