Abstract #2478

Accelerating High-Resolution Semi-LASER 1H-MRSI Using SPICE

Yibo Zhao^1,2, Yudu Li^1,2, Rong Guo^1,2, Bryan Clifford^1,2, Xin Yu³, and Zhi-Pei Liang^1,2

¹Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ²Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, Urbana, IL, United States, ³Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

Most of the current ¹H-MRSI techniques have several major practical limitations, including long data acquisition time, low spatial resolution and poor SNR. To overcome these limitations, we accelerate the semi-LASER technique by incorporating subspace modeling. With this improvement, semi-LASER is cable of achieving 1.9×1.6 mm² resolution in a 1.5 minutes scan, which is a significant improvement over the conventional semi-LASER. This imaging capability has been validated with in vivo experiments, and it may significantly enhance the practical utility of ¹H-MRSI.

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