Patient-derived xenografts in NSG mice provide a novel and more clinically relevant model of studying breast cancer brain metastasis in comparison to traditional cell lines in nude mice. NSG and nude mice both received brain-seeking breast cancer cells and were imaged with MRI to assess cell arrest, retention, and growth. Images revealed significantly more brain metastases and overall whole-body tumour burden in NSG mice than nudes. These results provide characterization of the NSG mouse as a preclinical platform for PDX models and demonstrates the importance of imaging to establish this model for future advancements in drug development and personalized medicine.
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