Abstract #2277

Blood plasma metabolic profiling discriminates prostate cancer patients with metastases from those without metastases

Naranamangalam R Jagannathan¹, Pradeep Kumar¹, Rajeev Kumar², Virendra Kumar¹, S. Senthil Kumaran¹, Sanjay Sharma³, Sanjay Thulkar³, and S. Datta Gupta⁴

¹Department of NMR and MRI Facility, All India Institute of Medical Sciences, New Delhi, India, ²Department of Urology, All India Institute of Medical Sciences, New Delhi, India, ³Department of Radio-diagnosis, All India Institute of Medical Sciences, New Delhi, India, ⁴Department of Pathology, All India Institute of Medical Sciences, New Delhi, India

The present study evaluates the metabolic profile of blood plasma for distinguishing prostate cancer (PCa) patients with metastases (n=30) and without metastases (n=35) using ¹H-NMR spectroscopy. Our data showed significant lower concentration of leucine, valine, isoleucine, glycerophosphocholine, glutamine and acetoacetate in PCa patents with metastases as compared to patients without metastases. Results provided an insight into the alterations in the metabolic pathways in PCa and indicated that NMR spectroscopy may help in determining potential biomarker/s for the diagnosis of PCa patients with metastases.

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