Abstract #2235

Simultaneous modelling of Hadamard encoded spectra for GABA and GSH using LCModel

Diana G. Rotaru¹, Georg Oeltzschner^2,3, Richard Edden^3,4, and David J. Lythgoe¹

¹Neuroimaging, King's College London, London, United Kingdom, ²Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States

Low-concentration metabolites like γ-aminobutyric acid (GABA) and glutathione (GSH) can be measured at 3T using spectral-editing magnetic resonance spectroscopy methods like MEGAPRESS, HERMES or HERCULES. We propose a novel analysis approach based on simultaneous modelling of HERMES difference and sum spectra in LCModel, instead of fitting the difference spectra separately. This approach uses all available spectral information. It improves the quality of the results providing high reproducibility, and lower Cramér-Rao lower bounds values (CRLB) compared to traditional analysis.

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