Abstract #2234

Reliability of in vivo Glx measurements from GABA-edited MRS at 3T

Tiffany Kay Bell^1,2,3, Elodie S Boudes^1,2,3, Rachelle S Loo^1,2,3, Gareth J Barker⁴, David J Lythgoe⁴, Richard AE Edden^5,6, R Marc Lebel⁷, Martin P Wilson⁸, and Ashley D Harris^1,2,3

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Department of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, London, United Kingdom, ⁵Russel H Morgan Department of Radiology, The Johns Hopkins School of Medicine, Baltimore, MD, United States, ⁶F.M. Kirby Centre for Functional MRI, Kennedy Krieger Institute, Baltimore, MD, United States, ⁷General Electric Healthcare, Calgary, AB, Canada, ⁸School of Psychology, University of Birmingham, Birmingham, United Kingdom

To measure glutamate and GABA, two spectroscopy sequences are typically performed. Here we investigate the reliability of measuring Glx (glutamate+glutamine) from the same editing sequence used to measure GABA (MEGA-PRESS). We found that Glx measured using the unedited (“off”) sub-spectra of a macromolecule suppressed MEGA-PRESS sequence (MM-suppressed, TE=80ms) moderately agreed with Glx measured using a short-echo PRESS sequence. However, Glx measured using the off sub-spectra of a GABA+ (TE=68ms) MEGA-PRESS sequence and the co-edited Glx signal from the difference spectra of both GABA-edited MEGA-PRESS sequences showed poor agreement.

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