Abstract #2085

Volumetric assessment of arteriosclerotic plaque burden in ApoE-KO mice using high resolution MR microscopy

Courtney Whalen¹, Alexandra Caamano², Floyd Mattie¹, Lukas Neuberger³, Neil Kuan-Hsun Huang¹, Catharine Ross¹, Rita Castro^1,4, and Thomas Neuberger^5,6

¹Nutritional Sciences, The Pennsylvania State University, University Park, PA, United States, ²The Pennsylvania State University, University Park, PA, United States, ³State College Are High School, State College, PA, United States, ⁴University of Lisbon, Lisbon, Portugal, ⁵Huck Institute of the Life Science, University Park, PA, United States, ⁶Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States

There is a need to address current knowledge gaps in atherosclerosis' etiology to develop successful strategies to reduce mortality due to this disease. In this study, we investigated the feasibility of using 14T MR microscopy to measure the extent of atherosclerosis in apoE-KOmice on diet studies. Results from the ex-vivo 3D MR microimaging of the aortic atherosclerotic plaques with a resolution of 10x10x15µm³ are presented. A contrast agent was used to increase the sensitivity of the 14-tesla system and provide the resolution necessary to assess in detail the wall vessel changes associated with the atherosclerotic process.

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