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Abstract #2084

Identification of Intrapalque Hemorrhage in Carotid Artery by Simultaneous Non-contrast Angiography and intraPlaque hemorrhage (SNAP) Imaging: Validation by Histology

Dongye Li1,2, Huiyu Qiao1, Yongjun Han1, Hualu Han1, Dandan Yang1,2, Jingli Cao3,4, Huimin Xu5, Tao Wang6, and Xihai Zhao1

1Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University of Medicine, Beijing, China, 2Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain Disorders, Beijing, China, 3Beijing Tiantan Hospital, Capital Medical University, Beijing, China, 4China National Clinical Research Center for Neurological Diseases, Beijing, China, 5Department of Radiology, Peking University Third Hospital, Beijing, China, 6Department of Neurosurgery, Peking University Third Hospital, Beijing, China

It is important to accurately characterize carotid intraplaque hemorrhage (IPH) due to its strong association with plaque progression and ischemic stroke. Previous study proved that MP-RAGE is the best T1-weighted sequence in detecting carotid IPH. Most recently, investigators found that SNAP imaging can detect more IPHs compared with MP-RAGE. This study sought to investigate the performance of SNAP imaging in evaluating carotid IPH validated by histology. We found that SNAP sequence showed better agreement with histology compared with MP-RAGE in assessing IPH, suggesting that SNAP imaging might be a more sensitive and accurate imaging approach in characterizing carotid IPH.

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