Abstract #2010

Assessing myocardial infarct size by novel TRAFFn relaxation time method in lymphatic insufficient mice

Elias Yla-Herttuala¹, Taina Vuorio¹, Svetlana Laidinen¹, Seppo Yla-Herttuala^1,2, and Timo Liimatainen^3,4

¹A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland, ²Heart Center, Kuopio University Hospital, Kuopio, Finland, ³Research unit of medical imaging, physics and technology, University of Oulu, Oulu, Finland, ⁴Department of diagnostic radiology, Oulu University Hospital, Oulu, Finland

We applied novel RAFFn relaxation times (T_RAFF2 and T_RAFF4), T_1ρ and T₂ to study effects of cardiac lymphatic system in myocardial infarct (MI). Infarct size based on the T_RAFF4 relaxation time maps was significantly larger in earlier time points post MI in wild-type compared to lymphatic insufficient mice groups. No differences were found in relaxation times between groups. Area-of-overestimation (AOE) values remained stable in lymphatic insufficient group while in wild-type group a decreasing trend of AOE was observed. We conclude that effects of lymphatics after MI can be detected based on infarct size difference measured with different relaxation times.

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