Abstract #1887

Comparing Hyperpolarized 3He MRI Fractional Ventilation to CT-Derived Fractional Ventilation

Ryan Baron¹, Faraz Amzajerdian¹, Stephen Kadlecek¹, Hooman Hamedani¹, Ian Duncan¹, Yi Xin¹, Mehrdad Pourfathi¹, Francisca Bermudez¹, Maurizio Cereda², and Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States, ²Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, PA, United States

Although hyperpolarized helium-3 (HP 3He) MRI has been viewed as the gold-standard for ventilation imaging of the lungs, validating fractional ventilation (FV) measurements obtained with HP 3He MRI has proven challenging, as no other technique delivers qualitatively comparable information regarding gas distribution throughout the lungs. In this work, we assessed the feasibility of deriving CT-based FV assessments from end-inspiratory (EI) and end-expiratory (EE) images obtained from subjects in the national COPDGene study, to be used for validation of FV measurements obtained during HP 3He MRI.

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