Abstract #1886

Jacobian-based Ventilation Derived from Lung Proton MRI: Correlation with Ventilation Defects on Hyperpolarized Gas MRI

Katherine J Carey¹, David G Mummy^1,2, Wei Zha¹, Michael D Evans³, Mark L Schiebler⁴, Ronald L Sorkness⁵, Nizar N Jarjour⁶, Loren C Denlinger⁶, and Sean B Fain^1,2,4

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States, ³Biostatistics and Medical Informatics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Radiology, University of Wisconsin-Madison, Madison, WI, United States, ⁵Pharmacy, University of Wisconsin-Madison, Madison, WI, United States, ⁶Allergy, Pulmonary, & Critical Care Medicine, University of Wisconsin-Madison, Madison, WI, United States

We used deformable registration between ¹H MRI at two lung volumes to create a Jacobian based ventilation map for quantification of ventilation heterogeneity. We compared values derived from the Jacobian ventilation map to the ventilation defect percent (VDP) from hyperpolarized Helium-3 MRI (HP ³He MRI) and to spirometry measures and found that the Jacobian minimum was associated with both VDP and FEV1/FVC %. These findings suggest that ventilation quantified using Jacobian maps of deformable registration on ¹H MRI is a potential alternative to HP MRI ventilation imaging.

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