Abstract #1854

One millimeter isotropic breast DWI combining readout-segmented EPI, super-resolution and simultaneous multi-slice acceleration: validation in a diffusion/resolution phantom and volunteers.

Maya Delbany¹, Roman Fenioux¹, Isabelle Thomassin-Naggara², Jacques Felblinger^1,3, Pierre-André Vuissoz¹, and Freddy odille³

¹IADI, INSERM U1254 and Université de Lorraine, Nancy, France, ²Laboratoire de Recherche en Imagerie INSERM / Université Paris Descartes, Sorbonne Paris Cité, PARCC UMR 970, Faculté de médecine, Paris, France, ³CIC-IT 1433, INSERM, CHRU de Nancy and Université de Lorraine, Nancy, France

The low resolution of diffusion-weighted imaging (DWI) is the main limiting factor in screening breast MRI. Recently a method was proposed for one millimeter isotropic DWI covering the entire breasts. Based on a readout-segmented DW-EPI sequence, 3 stacks of thick slices (3 mm) are acquired with 1mm-shifts in the slice direction; then a 1x1x1 mm³ dataset is obtained using a super-resolution reconstruction (SRR). In this study we further validate the method using a commercial diffusion breast phantom, in terms of SNR, resolution and ADC values. Additionally, SMS acceleration is investigated to reduce the total scan time below 10 min.

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