Abstract #1745

Gadoxetic acid-enhanced perfusion quantification in the liver and spleen in portal hypertension

Stefanie Hectors^1,2, Octavia Bane^1,2, Paul Kennedy^1,2, Scott Friedman³, Thomas Schiano³, Maria Isabel Fiel⁴, Swan Thung⁴, Aaron Fischman⁵, and Bachir Taouli^1,2

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Department of Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States

The goal of our study was to assess the potential value of perfusion quantification using DCE-MRI with gadoxetic acid in the liver and spleen for noninvasive assessment of portal hypertension (PH). We found that the liver uptake fraction was significantly negatively correlated with hepatic venous pressure gradient measurements. We conclude that liver perfusion quantification is promising for noninvasive assessment of PH. After validation of these findings in a larger cohort of patients, DCE-MRI may potentially decrease the need of invasive portal pressure measurements.

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