Abstract #1744

Assessment of Spin-Echo and Gradient-Echo Liver MRE in Healthy Children and Children with Suspected Fibrosis at 3 T

Tess Armstrong¹, Sarai G. Santos², Karrie V. Ly², Ely Felker¹, Shahnaz Ghahremani¹, Xinran Zhong^1,3, Robert S. Venick², Joanna Yeh², Grace Hyun J. Kim¹, Kyunghyun Sung¹, Kara L. Calkins², and Holden H. Wu¹

¹Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ²Pediatrics, University of California Los Angeles, Los Angeles, CA, United States, ³Physics and Biology in Medicine IDP, University of California Los Angeles, Los Angeles, CA, United States

Magnetic resonance elastography (MRE) accurately measures liver stiffness and correlates with liver histopathology. However, conventional gradient-echo (GRE) MRE sequences require multiple breath-holds. Spin-echo echo-planar-imaging (SE-EPI) MRE only requires a single breath-hold. In this study we compared 2D SE-EPI and 2D rapid-GRE MRE sequences at 3T in healthy children and children with suspected fibrosis. Both SE-EPI and rapid-GRE had good repeatability, reproducibility, inter-reader agreement, and quantitative agreement in liver stiffness. SE-EPI provided larger measurable liver ROI sizes than rapid-GRE. SE-EPI may be desirable for measuring fibrosis in children with limited or inconsistent breath-hold ability and reduce scan times.

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