Improving the accuracy of Blood Oxygen Level Dependent Imaging using FLASH normalised T2 prepared SSFP acquisition
Betty Raman1, Kenneth Chan 1, Rina Ariga 1, Moritz Hundertmark1, Masliza Mahmod 1, Stefan Neubauer 1, Aaron Hess1, and Elizabeth Tunnicliffe 1
1Radcliffe Department of Medicine, Oxford Centre for Clinical Magnetic Resonance Research, University of Oxford, Oxfordshire, United Kingdom
T2-prepared steady state free precession (SSFP) Blood Oxygen Level Dependent (BOLD) imaging is a promising technique for ischaemia detection but has wide normal ranges, in part because the signal intensity is heart-rate dependent. Fast low angle shot (FLASH) readouts can be interleaved with the SSFP readouts to normalise SSFP images, rendering it heart-rate insensitive. In this study, we examined the variability and reproducibility of standard and FLASH-normalised T2-prepared SSFP BOLD in healthy subjects. FLASH-normalised T2-prepared SSFP BOLD produced a highly reproducible normal BOLD range with an effect size similar to that of the standard method and with considerably reduced variability.
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