Abstract #1219

Quantitative 129Xe MRI detects early impairment of gas-exchange in a rat model of pulmonary arterial hypertension

Rohan S Virgincar¹, John C Nouls², Simone Degan², Xinyu Xiong³, Ziyi Wang¹, Yi Qi², Sudarshan Rajagopal³, and Bastiaan Driehuys^1,2

¹Biomedical Engineering, Duke University, Durham, NC, United States, ²Radiology, Duke University Medical Center, Durham, NC, United States, ³Department of Medicine, Duke University Medical Center, Durham, NC, United States

Hyperpolarized ¹²⁹Xe MRI is capable of regional mapping of gas-exchange and has found application in a wide range of lung disorders. Here, we apply ¹²⁹Xe gas exchange MRI and dynamic spectroscopy at 7 Tesla to study a rat model of pulmonary arterial hypertension. ¹²⁹Xe spectroscopy and gas-exchange imaging showed reduced uptake by RBCs early in the progression of the disease, and at later time points was accompanied with increased uptake by barrier tissues, structural abnormalities, edema, and ventilation defects. Imaging results were compared to H&E histology, which showed evidence of vascular remodeling.

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