Abstract #1123

QSM and R2* measurements from cortical and subcortical regions of the human brain at 7T: a Multi-Centre Reproducibility Study

Catarina Rua¹, William T Clarke², Ian D Driver³, Olivier Mougin⁴, Andrew T Morgan⁵, Stuart Clare², Sue Francis⁴, Keith Muir⁵, David Porter⁵, Richard Wise³, Adrian Carpenter¹, Guy Williams¹, Christopher T Rodgers¹, and Richard Bowtell⁴

¹Wolfson Brain Imaging Centre, University of Cambridge, Cambridge, United Kingdom, ²Welcome Centre for Integrative Neuroimaging (FMRIB), University of Oxford, Oxford, United Kingdom, ³Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Cardiff, United Kingdom, ⁴Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ⁵Imaging Centre of Excellence, University of Glasgow, Glasgow, United Kingdom

Multi-site studies allow for cost-effective research at high-field by increasing the size of the healthy and patient pool.

For T2*-weighted imaging, the variability in the scanners’ shimming conditions may contribute to inconsistent numerical results.In this study we present a multi-site, multi-vendor ‘travelling-heads’ study with harmonized protocols for QSM and R2*-mapping.

Average values across cortical and subcortical ROIs are in agreement with literature, show low variance and high correlation values when comparing measurements across different scanners. R2*-mapping is more stable than QSM due to shimming differences across scanners that affect the background field.

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